报告题目：Structure and Function of DNA G-quadruplexes and Its Potential as Anticancer Drug Target

报告时间：2017年6月13日（周二）14:00-16:00

报告地点：校本部.图书馆五楼第二学术报告厅

报 告 人：Danzhou Yang  教授（美国普渡大学药学院）

主办单位：基于靶点的药物设计与研究教育部重点实验室

          中药学院

   研究生处（学科建设办公室）

          辽宁省研究生现代药物领域创新与交流中心

          辽宁省研究生传统药物领域创新与交流中心

报告人简介：

  YANG, DANZHOU. Professor, College of Pharmacy, Purdue University. The Martha and Fred Borch Chair in Cancer Therapeutics. University of Science & Technology of China, Mol. & Cell Biology, BS, 1989. University of Illinois at Urbana-Champai, Biophysics, PHD, 1996. University of Kentucky, Pharm. & Med. Chem, Postdoctoral Fellow, 1998. 2001-2016, Assistant Professor-Professor, University of Arizona. 2016-now, Professor, College of Pharmacy, Purdue University.

  1. Ambrus A, Chen D, Dai J, Bialis T, Jones RA, Yang D. (2006) Human telomeric sequence forms a hybrid-type intramolecular Gquadruplex structure with mixed parallel/antiparallel strands in potassium solution. Nucleic Acids Res, 34(9), 2723-35. PMID:16714449. Times Cited: 716

  2. Ambrus A, Chen D, Dai J, Jones RA, Yang D. (2005) Solution structure of the biologically relevant G-quadruplex element in the human c-MYC promoter. Implications for G-quadruplex stabilization. Biochemistry, 44(6), 2048-58. PMID: 15697230. Times Cited: 310

  3. Dai J, Carver M, Hurley LH, Yang D. (2011) Solution structure of a 2:1 quindoline-c-MYC G-quadruplex: insights into G-quadruplexinteractive small molecule drug design. J Am Chem Soc, 133(44), 17673-80. PMID: 21967482 Times Cited: 110

报告内容简介：

     G-四链体作为潜在的抗肿瘤靶标，其结构与功能的相关研究。