报告题目：Towards the development of a theranostic system for lung cancer
报告时间：10月22日（周四） 15:30-17:00
报告地点：老科研楼五楼501研究生学术报告厅
报 告 人：Prof. Timothy Wiedmann（美国明尼苏达大学）
主办单位：药剂学学科
药学院
研究生处（学科建设办公室）
国际交流处
辽宁省研究生现代药物领域创新与交流中心
聆听无涯论坛 拓宽学术视野
欢迎各位老师和同学们踊跃参加！
报告内容简介
A theranostic system comprises two essential components; one for the diagnosis or assessing the status of the disease, and the other, treatment of the disease. Our long-term goal is to find a cure for lung cancer, which theoretically can be achieved with a theranostic system. For this goal, we envision the delivery as a sequence of steps that ultimately directs the diagnosis/treatment to the cancer cell, while leaving normal cells unaffected. We have focused on superparamagnetic nanoparticles, which are currently used as a contrast agent in magnetic resonance imaging (MRI) of the lung. Such particles will also undergo heating, when exposed to an oscillating magnetic field, and are used to produce hyperthermia for the treatment of testicular cancer. The key aspects of the system of interest are: (1) inhalation, limiting exposure to the affected organ, (2) magnetic guided deposition, limiting particles to the affected portion of the lung, and (3) selective activation of particles, limiting hyperthermia/drug release to the localized regions of the site of cancer. During the presentation, the in vitro and in vivo magnetic guided, enhanced deposition of aerosols of iron oxide (magnetite; Fe3O4) nanoparticles will be shown. Complementary numerical simulations were performed, which did not involve adjustable parameters, and the results were found to be in excellent agreement with both the in vitro and in vivo deposition. Thereafter, I will present the use of magnetic nanoparticles in providing controllable “on-off” drug release. Specifically, myristoyl alcohol was loaded with magnetic nanoparticles and a fluorescent compound; the latter was released upon heating by exposure to an oscillating magnetic field that induced melting of the lipid matrix. Finally, we conducted studies examining the distribution of an infrared fluorescent dye in mouse lungs immediately following exposure to aerosols that varied with respect to aerodynamic size. While such an approach in humans has theoretical challenges, it can provide an efficient, economic, and high resolution approach for evaluating efficacy of cancer treatments in rodents. In conclusion, I will describe our future direction of the use of asymmetric (rice-shaped) iron oxide particles. These have the potential for enhanced deposition at lower applied magnetic fields. In addition, cell death may be achieved with a single particle through mechanical disruption of the cell membrane. Finally, gold coated asymmetric particles are amenable for Plasmon resonance, which would provide directed therapy with laser precision.
