个人情况介绍、概览

张欣，男，博士，副教授。博士/硕士生导师。2011年毕业于沈阳药科大学药学日语专业，获理学学士学位，2014年获沈阳药科大学药剂学硕士学位，2018年于同校获药剂学博士学位，2017-2018年赴美国波士顿Northeastern University CPBN研究中心进行国家公派学习。作为课题负责人主持国家自然科学基金、博士后面上项目、药典委辅料标准提高项目、辽宁省科技厅、辽宁省教育厅面上项目等支持。发表SCI文章50余篇，H指数30。相关研究获得辽宁省自然科学奖二等奖（第二完成人）、辽宁省自然科学学术成果奖二等奖（第一完成人）。主要研究方向包括：生物大分子及难溶性药物智能仿生递送系统设计与评价，黏膜递药系统设计与评价，药用辅料粉体学等相关研究。

人才称号、社会兼职等（限填10项）

1. 中国颗粒学会青年理事

2. 辽宁省药学会药剂专委会委员

3.《Asian Journal of Pharmaceutical Sciences》青年编委

4.《European Journal of Pharmaceutics and Biopharmaceutics》青年编委

5.《沈阳药科大学学报》青年编委

6.《中国粉体技术》编委

8. 辽宁省“百千万人才工程”“万”层次（2020年）

9. 沈阳市兴沈英才-领军人才

主要研究方向（限填3项）

研究方向一：生物大分子智能仿生递送系统设计与评价

研究方向二：黏膜递药系统研究

研究方向三：药物制剂粉体学研究

主持、参与的科研项目（含科研获奖等情况）（限填10项）

1.国家自然科学基金：动态组装仿生乳糜微粒定向驱动生物大分子跨肠黏膜屏障机制，2022。

2.中国博士后科学基金面上项目：吸入仿生纳米载体技术调控肺内微环境清除的前沿应用研究，2021。

3.国家药典委员会辅料标准提高项目：粉体压缩特性测定法研究，2022。

4.辽宁省科技厅面上项目：仿生伴侣复合物脂质营养转运途径协同互作模式调控生物大分子肠黏膜屏障机制, 2024。

5.辽宁省教育厅面上项目：动态捕获内源性胆酸智能仿生载体促生物大分子跨肠黏膜吸收机制, 2023。

6.辽宁省教育厅，仿生纳米载体促黏膜渗透机制研究，2019。

7.辽宁省自然科学奖：二等奖，排名第2

8.辽宁省自然科学学术成果奖：二等奖，排名第1

9.华海药业青年学者创新基金,2023

近年来发表代表性论文(限第一作者或通讯作者，SCI须写明影响因子)：（限填10篇）

(1) Shuman Cui; Yalin An; Zhixiang Cui; Shiyun Liu; Hongfang Li; Xiangce Wen; Jian Guan; Shirui Mao; Han Yi*; Xin Zhang*; Design of biomimetic chylomicrons based on 1,3-diolein grafted hyaluronic acid to drive biomacromolecules across the intestinal mucosal barrier, Journal of Controlled Release, 2026, 390: 114504(IF 11.5003).

(2) Qiyao Zhai; Shuang Guo; Zhixiang Cui; Lu Qin; Jian Guan; Xin Zhang*; Shirui Mao*; Exploration of a dual-mimetic mucus inert nanocomplex for enhanced oral insulin delivery, European Journal of Pharmaceutics and Biopharmaceutics, 2026, 220: 114970(IF 4.2997).

(3) Ying Mao; Luyao Chen; Ying Liu; Jinlin Song; Peng Liu; Mengyue Zhang; Shiwen Wu; Jian Guan; Xin Zhang*; Yixuan Zhang*; Shirui Mao*; Enhanced brain targeting and improved Alzheimer's disease therapy via intranasal delivery of Ginsenoside F1-loaded mixed micelles, Colloids and Surfaces B: Biointerfaces, 2026, 262: 115551(IF 5.5999).

(4) Shiyun Liu, Xiangce Wen, Xin Zhang*, Shirui Mao*, Oral delivery of biomacromolecules by overcoming biological barriers in the gastrointestinal tract: an update，Expert Opinion on Drug Delivery,2023, 20(11):1-15(IF 6.6002).

(5)Cui, Zhixiang; Liu, Chang; Cui, Shuman; Qin, Lu; Zhang, Xin*; Guan, Jian; Mao, Shirui*.Exploring the potential of redispersible nanocomplex-in-microparticles for enhanced oral insulin delivery, Int J Pharmaceut, 2022, 612,121357(IF 6.510).

(6)Hezhi Wang , Lu Qin , Zhang, Xin* , Jian Guan, Shirui Mao*.Mechanisms and challenges of nanocarriers as non-viral vectors of therapeutic genes for enhanced pulmonary delivery, Journal of Controlled Release, 2022, 612, 121357(IF 10.7997).

(7)Zhang, Xin; Pan, Jiayi; Yao, Momei; Mendes, Livia Palmerston; Sarisozen, Can; Mao, Shirui*; Torchilin, Vladimir P*. Charge reversible hyaluronic acid-modified dendrimer-based nanoparticles for siMDR-1 and doxorubicin co-delivery. European Journal of Pharmaceutics and Biopharmaceutics, 2020, 154: 43-49(IF 5.589).

(8)Zhang, Xin; Dong, Wei; Cheng, Hongbo; Zhang, Meixia; Kou, Yongqiang; Guan, Jian; Liu, Qiaoyu; Gao, Mingyue; Wang, Xiuhua; Mao, Shirui*. Modulating intestinal mucus barrier for nanoparticles penetration by surfactants. Asian Journal of Pharmaceutical Sciences, 2019, 14(5): 543-551(IF 3.968).

(9)Zhang, Xin; Zhao, Jing; Guan, Jian; Zhang, Xiaofei; Li, Liang; Mao, Shirui*.Exploration of nanocrystal technology for the preparation of lovastatin immediate and sustained release tablets. Journal Of Drug Delivery Science and Technology, 2019, 50: 107-112(IF2.7340).

(10)Zhang, Xin; Cheng, Hongbo; Dong, Wei; Zhang, Meixia; Liu, Qiaoyu; Wang, Xiuhua; Guan, Jian; Wu, Haiyang; Mao, Shirui*. Design and intestinal mucus penetration mechanism of core-shell nanocomplex. Journal of Controlled Release, 2018, 272: 29-38 (IF 7.9008).

主编或参编的教材、专著（限填10项）

(1)《药剂学》，中国中医药出版社，2023，参编

(2)《药剂学》，中国医药科技出版社，2025，参编

(3) Zhang Xin; Mao Shirui; Recent development in mucosal drug delivery system, in Amit Kumar Nayak, Kalyan Kumar Sen(eds), Novel Formulations and Future Trends, Academic Press, Elsevier, 2024, p 61-84.

(4)Zhang Xin, Guan Jian, Mao Shirui. Mucoadhesive Chitosan-Based Nanoparticles for Oral Drug Delivery, in Emmanuel C. Opara (ed), Controlled Drug Delivery Systems, CRC press, 2020, p 275-296.

(5)Zhang Xin, Li L, Mao Shirui*, Drug Delivery Applications of Chitosan and its Derivatives, in Ajit S Narang, Sai H S. Boddu (eds), Excipient Applications in Formulation Design and Drug Delivery, Springer, p 637-678.

(6)Zhang Xin, Guan Jian, Mao Shirui. Applications of hybrid nanocrystals in drug delivery. in Hybrid Nanomaterials for Drug Delivery, 2021，Elsevier.