个人情况介绍、概览

孙孟驰，男，博士，特聘教授/副教授，博士生导师。2020年获沈阳药科大学药剂学博士学位，同年入沈阳药科大学中药学流动站进行博士后研究。2022年通过校高层次引进人才政策留校，现为药学院药剂教研室特聘教授/副教授，2023年遴选为博士生导师。在Nature Communication, Advanced Materials, Advanced Science, Nano Letters, ACS nano等期刊以第一作者/通讯作者（含共同）身份已发表SCI论文30篇，IF>20的论文2篇，IF>10的论文21篇，一区论文25篇，申请专利5项，授权专利3项。

人才称号、社会兼职等

1.2023年沈阳药科大学“优青”托举计划（编号：YQ202301）

2.2023年中国抗癌协会纳米肿瘤学专业委员会青年委员会委员

3.2023年本溪市高层次人才 第四层次

4.2022年沈阳市拔尖人才（编号：2022-4-1990903）

5.2021年辽宁省优秀博士学位论文（编号：LNYB2021073）

6.《Asian Journal of Pharmaceutical Sciences》期刊青年编委

7.《Acta Materia Medica》期刊青年编委

8.《Nano TransMed》期刊青年编委

9.《Asian Journal of Traditional Medicines》期刊青年编委

主要研究方向

研究方向一：基于溶瘤细菌/益生菌等活体微生物药物智能递送系统的研究

研究方向二：基于临床问题的外泌体递送系统研究

研究方向三：基于计算机模拟的纳米药物研究

主持、参与的科研项目（含科研获奖等情况）

1.国家自然科学基金面上项目，主持，项目编号：82372111

2.辽宁省科技厅博士科研启动基金，主持，项目编号：2022-BS-157

3.辽宁省教育厅面上项目，主持，项目编号：LJKZ0927

4.辽宁省教育厅青年项目，主持，项目编号：LJKQZ2021034

5.中国博士后科学基金面上资助，主持，项目编号：2020M680986

近年来发表代表性论文(限第一作者或通讯作者，SCI须写明影响因子)：

1.Weiyue Ban^#,Mengchi Sun^#（共同第一作者）, Hanwei Huang^#, Wanxu Huang^#, Siwei Pan, Pengfei Liu, Bingwu Li, Zhenguo Cheng, Zhonggui He, Funan Liu* and Jin Sun*. Engineered bacterial outer membrane vesicles encapsulating oncolytic adenoviruses enhance the efficacy of cancer virotherapy by augmenting tumor cell autophagy.Nature Communication,2023,14:2933. (IF=17.694)综合一区

2.Xinyu Lou, Jinqiang Wang, Xiru Jin, Xu Wang, Bin Qin, DongchunLiu, Xianbao Shi, Defang Ouyang, Zhonggui He, Jin Sun*, Hongjun Li* andMengchi Sun*. An oral bacterial pyroptosis amplifier against malignant colon cancer.Nano Today, 2024, 54, 102091.(IF=17.4)材料科学一区

3.Hao Ling^#, Qinyi Zhang^#, Qiuhua Luo^#, Defang Ouyang, Zhonggui He,Jin Sun*andMengchi Sun*.Dynamic immuno-nanomedicines in oncology.Journal of Controlled Release, 2024, 365, 668-687.(IF=10.8)药学一区

4.Zhichao Chen, Yuhan Liu, Yuxuan Yu, Shihua Yang, Jing Feng, Yinmei Zhu, Wanxu Huang, Bin Qin, Xinyao Guan, Zhonggui He,Mengchi Sun*and Jin Sun*. Micro-to-nano oncolytic microbial system shifts from tumor killing to tumor draining lymph nodes remolding for enhanced immunotherapy.Advanced Materials, 2023. DOI: 10.1002/adma.202306488.(IF=29.4)材料科学一区

5.Mengchi Sun^#, Shihua Yang^#, Hanwei Huang^#, Peng Gao^#, Siwei Pan, Zhenguo Cheng, Zhonggui He,Zhenning Wang*, Jin Sun*, and Funan Liu*. Boarding Oncolytic Viruses onto Tumor-Homing Bacterium-Vessels for Augmented Cancer Immunotherapy.Nano Letters, 2022, 22(12): 5055-5064. (IF=12.262)材料科学一区

6.Mengchi Sun^#, Wen Shi^#,Yuxia Wu, Zhonggui He, Jin Sun,Shuang Cai*, andQiuhua Luo*. Immunogenic Nanovesicle-Tandem-Augmented Chemoimmunotherapy via Efficient Cancer-Homing Delivery and Optimized Ordinal-Interval Regime.Advanced Science,2022, 10(1): e2205247. (IF=17.521)材料科学一区

7.Mengchi Sun, Hailun Jiang, Tian Liu, Xiao Tan, Qikun Jiang, Bingjun Sun, Yulong Zheng, Gang Wang, Yang Wang, Maosheng Cheng, Zhonggui He* and Jin Sun*. Structurally defined tandem-responsive nanoassemblies composed of dipeptide-based photosensitive derivatives and hypoxia-activated camptothecin prodrugs against primary and metastatic breast tumors.Acta Pharmaceutica Sinica B, 2022, 12(2): 952-966. (IF=14.903)药学一区

8.Xinyu Lou^#, Zhichao Chen^#, Zhonggui He,Mengchi Sun*and Jin Sun*. Bacteria‑mediated synergistic cancer therapy: small microbiome has a big hope.Nano-Micro Letters, 2021, 13(1): 37. (IF=23.655)材料科学一区

9.Mengchi Sun, Hao Ye, Qinghua Shi, Jun Xie, Xiang Yu, Hao Ling, Song You, Zhonggui He, Bin Qin* and Jin Sun*. Both-in-one hybrid bacteria suppress the tumor metastasis and relapse via tandem-amplifying reactive oxygen species-immunity responses.Advanced Healthcare Materials,2021, 10(21): e2100950. (IF=11.092)工程技术一区

10.Mengchi Sun^#,Xiangyu Zhang^#, Zisen Gao, Tian Liu, Cong Luo, Yongshan Zhao, Yun Liu, Zhonggui He, Jian Wang*andJin Sun*.Probing a dipeptide-based supramolecular assembly as an efficient camptothecin delivering carrier for cancer therapy: computational simulations and experimental validations.Nanoscale, 2019, 11(9):3864-3876. (IF=7.790)工程技术一区

专利及其他

1.孙孟驰、孙进、刘福囝、班玮越，基于工程化细菌外膜囊泡的溶瘤病毒静脉递送系统及其构建方法和应用。申请专利号：202210914720.3

2.孙孟驰、孙进、李吉威、刘林林、杨伟光，基于工程化益生菌外膜囊泡包被纳米酶递送系统及其制备方法和应用。申请专利号：202210996939.2

3.孙孟驰、孙进、何仲贵、赵芳雪、张汐铭，紫杉醇-苯硼酸前药及其前药纳米脂质体及制备与应用。申请专利号：202310541770.6

4.孙孟驰、孙进、于雨璇，瘤内自增殖增强的溶瘤微生物递送系统的构建及其应用。申请专利号：2023116202801