个人情况介绍、概览
英国德蒙福特大学莱斯特药学院结晶科学与药物输送系教授。他在中国东北大学获得控制与仪器工程博士学位。目前,他的研究方向集中在结晶科学与工程、口服药物配方设计和输送以及药品制造领域。
主要研究方向
1. 研究方向一:药物共晶筛选和传递
2. 研究方向二:数字化连续制药生产过程设计和优化
3. 研究方向三:新型固体口服剂型的设计和传递
近年来发表代表性论文(限第一作者或通讯作者,SCI须写明影响因子):
1. Alinda, P., A. Botana, and M. Li, Insight into the Precipitation Inhibition of Polymers within Cocrystal Formulations in Solution Using Experimental and Molecular Modeling Techniques. Crystal Growth & Design, 2025. (IF=3.8)
2. M. A. N. Adegbolagun, K. Wang, T. Yamaguchi, T. Hamaguchi, K. Yoshida, S. Kawata, C.C. Seaton, A, Harano, J Han, Z. Wang & M. Li, Multicomponent Crystal Forms of Albendazole for Bioavailability Improvement. Crystal Growth & Design, 2025. 25(3): p. 540-553. (IF=3.8)
3. Madu, S. J., K. Wang, K., S.K. Chirumamilla, D.B. Turner, P.G. Steel, & M. LI. Assessing Dose-Exposure–Response Relationships of Miltefosine in Adults and Children using Physiologically-Based Pharmacokinetic Modeling Approach. Pharmaceutical Research, 2023, 40(12): 2983-3000. DOI: 10.1007/s11095-023-03610-0. (IF=3.5)
4. Shi, K. & Li, M. Optimisation of Pharmaceutical Cocrystal Dissolution Performance through a Synergistic Precipitation Inhibition. Pharmaceutical Research, 2023, 40(8), 2015-2069. DOI: 10.1007/s11095-023-03532-x. (IF=3.5)
5. Makadia, J., Seaton, C. C. & Li, M. Apigenin Cocrystals: From Computational Prescreening to Physicochemical Property Characterization. Crystal Growth & Design, 2023, 23, 3480-3495. DOI: 10.1021/acs.cgd.3c00030. (IF=3.8)
6. Hall, A.V., Gostick, I.E.F., Yufit, D.S., Marchant, G.Y., Kirubakaran, P., Madu, S.J., Li, M., Steel, P.G., and Steed, J.W., Integral Role of Water in the Solid-State Behavior of the Antileishmanial Drug Miltefosine. Crystal Growth & Design, 2022, 22 (10): 6262-66. DOI: 10.1021/acs.cgd.2c00843. (IF=3.8)
7. Alinda, P., Shi, K., and Li, M., Nucleation of Supersaturated Flufenamic Acid Cocrystal Solutions in the Presence of a Polymer. Crystal Growth & Design, 2022, 22(9), 5215-5228. DOI: 10.1021/acs.cgd.2c00323. (IF=3.8)
8. Makadia, J., Madu, S. J., Arroo, R., Seaton, C. C. Li, M., Artemisinin–acetylenedicarboxylic acid cocrystal: screening, structure determination, and physicochemical property characterisation. CrystEngComm, 2022, 24, p. 1056-1067. DOI: 10.1039/D1CE01400E.(IF=3.756)
9. Kaur, M., Yardley, V., Wang, K., Masania, J., Arroo, R., Turner, D., Li, M., Artemisinin Cocrystals for Bioavailability Enhancement: Part 2. In-vivo Bioavailability and PBPK Modelling, Molecular Pharmaceutics, 2021, 18(12): 4272-4289. DOI: 10.1021/acs.molpharmaceut.1c00385.(IF=4.5)
10. Kaur, M., Yardley, V., Wang, K., Masania, J., Botana, A. Arroo, R., Li, M., Artemisinin Cocrystals for Bioavailability Enhancement: Part 1. Formulation Design and Role of the Polymeric Excipient, Molecular Pharmaceutics, 2021, 18(12): 4256-4271. DOI: 10.1021/acs.molpharmaceut.1c00384. (IF=4.5)