个人情况介绍、概览

张继稳，博士，沈阳药科大学兼职教授，中国科学院上海药物研究所研究员、课题组长、博士研究生导师。1990年毕业于沈阳药科大学，获制剂工程专业学士学位，1993年于中国药科大学，获得药剂学硕士学位，2001年获沈阳药科大学药剂学博士学位。主要研究方向为结构药剂学、超分子给药系统。率先应用同步辐射光源成像技术，研究药物制剂及微粒的精细内部结构，提出“结构药剂学”新理论，发展了制剂结构一致性和辅料微粒结构研究新策略；以环糊精金属有机骨架为主，研究其独特的载药机制和应用，发展超分子新辅料和给药系统。主要研究的剂型包括渗透泵制剂、干粉吸入制剂和纳米制剂。作为课题负责人先后主持了多项国家自然科学基金、科技部、中科院等来源的项目，发表论文100余篇，申请专利40余项。

主要学术与社会兼职

1.International Journal of Pharmaceutics现任编委；

2.Asian Journal of Pharmaceutical Sciences现任编委；

3.Acta Pharmaceutica Sinica B现任编委；

4.世界中医药学会联合会中药新型给药系统专业委员会常务理事；

5.上海市药学会药剂学专业委员会委员；

6.中英Advanced Material Research Institute专家委员会委员；

7.分子药理和药物评价教育部重点实验室学术委员会委员;

8.中国药品监督管理研究会药品包材与辅料监督管理研究专业委员会委员。

主要研究方向

1.结构药剂学理论与应用研究。

2.超分子给药系统研究。

3.缓控释制剂研发。

在研项目

1.结构药剂学理论研究: 药物制剂的定量结构及其对药物释放的控制，81773645，国家自然科学基金面上项目，2017/01-2020/12，主持

2.桥接细胞与整体的纳米药代动力学研究，81430087，国家自然科学基金重点项目，2015/01-2019/12，参加

3.藏药大花红景天活性成分红景天苷的创新剂型，CASIMM0120182001，中国科学院药物创新研究院自主部署科研项目，2018/11-2021/8，主持

4.降低慢阻肺等老年呼吸疾病医疗费用的药物递送技术创新,S2016G7086，“政府间国际科技创新合作”重点专项，2017/4-2019/3，主持

5.个性化药物递送关键技术：提高难溶性候选药物可溶性的制剂技术，XDA12050307，“个性化药物”先导专项子任务，2018/1-2020/3，主持

近年发表的论文：

[1] Wei Zhang, Tao Guo, Caifen Wang, Yuanzhi He, Xi Zhang, Guangyu Li, Yizhi Chen, Jun Li, Yangjing Lin, Xu Xu, Li Wu*, Suxia Zhang*, Jiwen Zhang*. MOF Capacitates Cyclodextrin to Mega-Load Mode for High-Efficient Delivery of Valsartan. Pharm Res. 2019; 36(8):117.

[2] Liu Zhang, Shailendra Shakya, Li Wu, Jiangtao Wang, Guanghui Jin, Huimin Sun, Xianzhen Yin*, Lixin Sun**, Jiwen Zhang*. Multi-dimensional visualization for the morphology of lubricant stearic acid particles and their distribution in tablets.Asian Journal of Pharmaceutical Sciences. 2019;6:55.

[3] Jian Xu, Li Wu, Tao Guo, Guoqing Zhang, Caifen Wang, Haiyan Li, Xue Li, Vikramjeet Singh, Weidong Chen*, Ruxandra Gref*, Jiwen Zhang*. A “Ship-in-a-Bottle” strategy to create folic acid nanoclusters inside the nanocages of γ-cyclodextrin metal-organic frameworks. International Journal of Pharmaceutics. 2019; 556:89-96.

[4] Jian Xu, Xiaohong Ren, Tao Guo, Xian Sun, Xiaojin Chen, Laurence H. Patterson, Haiyan Li*, Jiwen Zhang*. NLG919/cyclodextrin complexation and anti-cancer therapeutic benefit as a potential immunotherapy in combination with paclitaxel. European Journal of Pharmaceutical Sciences. 2019; 138:105034.

[5] Yuehuai Xiong, Li Wu, Tao Guo, Caifen Wang, Wenting Wu, Yan Tang, Ting Xiong, Yong Zhou, Weifeng Zhu*, Jiwen Zhang*. Crystal Transformation of β-CD-MOF Facilitates Loading of Dimercaptosuccinic Acid. AAPS PharmSciTech. 2019; 20(6):224.

[6] Shailendra Shakya, Yaping He, Xiaohong Ren, Tao Guo, Abi Maharjan, Ting Luo, Tingting Wang, Ramesh Dhakhwa, Balmukunda Regmi, Haiyan Li*, Ruxandra Gref*, and Jiwen Zhang*. Ultrafine Silver Nanoparticles Embedded in Cyclodextrin Metal-Organic Frameworks with GRGDS Functionalization to Promote Antibacterial and Wound Healing Application. Small. 2019; 27(15):1901065.

[7] Wei Qin, Yuanzhi He, Zhen Guo, Liu Zhang, Li Wu, Xianzhen Yin, Shailendra Shakya, Abi Maharjan, Yan Tang, Weifeng Zhu*, Jiwen Zhang**. Optimization of taste-masking on ibuprofen microspheres with selected structure features. Asian Journal of Pharmaceutical Sciences. 2019; 2(14):174-182.

[8] Xiao Liang, Yulin Chen, Li Wu, Abi Maharjan, Balmukunda Regmie, Jiwen Zhang, Shuangying Gui*. In situ hexagonal liquid crystal for intra-articular delivery of sinomenine hydrochloride. Biomedicine & Pharmacotherapy. 2019; 117:108993.

[9] Xiaoxiao Hu, Caifen Wang, Lebing Wang, Zhaoxin Liu, Li Wu, Guoqing Zhang, Lin Yu, Xiaohong Ren, Peter York, Lixin Sun*, Jiwen Zhang*, Haiyan Li*. Nanoporous CD-MOF particles with uniform and inhalable size for pulmonary delivery of budesonide. International Journal of Pharmaceutics. 2019; 564:153-161.

[10] Yuanzhi He, Wei Zhang, Tao Guo, Guoqing Zhang, Wei Qin, Liu Zhang, Caifen Wang, Weifeng Zhu, Ming Yang, Xiaoxiao Hu, Vikramjeet Singh, Li Wu, Ruxandra Gref, Jiwen Zhang. Drug nanoclusters formed in confined nano-cages of CD-MOF: dramatic enhancement of solubility and bioavailability of azilsartan. Acta Pharmaceutica Sinica B. 2019; 9(1):97–106.

[11] Huanyu Ding, Li Wu, Tao Guo, Zaiyong Zhang, Bello Mubarak Garba, Ge Gao, Siyu He, Wei Zhang, Yizhi Chen, Yangjing Lin, Hewen Liu*, Jamshed Anwar*,and Jiwen Zhang*.

[12] Xianzhen Yin, Abi Maharjan, Longwei Fang, Li Wu, Liu Zhang, Shailendra Shakya,Wei Qin, Balmukunda Regmi, Peter York, Huimin Sun*, Jiwen Zhang**. Cavities spatial distribution confined by microcrystalline cellulose particles determines tablet disintegration patterns. Powder Technology. 2018; 339:717-727.

[13] Li Wu, Wei Qin, Yuanzhi He, Weifeng Zhu, Xiaohong Ren, Peter York, Tiqiao Xiao, Xianzhen Yin*, Jiwen Zhang*. Material distributions and functional structures in probiotic microcapsules. European Journal of Pharmaceutical Sciences. 2018; 122:1-8.

[14] Parbeen Singh, Xiaohong Ren, Tao Guo, Li Wu, Shailendra Shakya, Yaping He, Caifen Wang, Abi Maharjan, Vikramjeet Singh*, Jiwen Zhang*. Biofunctionalization of β-cyclodextrin nanosponges using cholesterol. Carbohydrate Polymers. 2018; 190:23-30.

[15] Liandi Chi, Lingxiao Chen, Jiwen Zhang, Jing Zhao, Shaoping Li, Ying Zheng*. Development and application of bio-sample quantification to evaluate stability and pharmacokinetics of inulin-type fructo-oligosaccharides from Morinda Officinalis. Journal of Pharmaceutical and Biomedical Analysis. 2018; 156:125-132.

[16] Xiaonan Xu, Caifen Wang, Haiyan Li, Xue Li, Botao Liu, Vikramjeet Singh, Shuxia Wang, Lixin Sun***, Ruxandra Gref**, Jiwen Zhang*. Evaluation of drug loading capabilities of γ-cyclodextrin-metal organic frameworks by high performance liquid chromatography. Journal of Chromatography A. 2017; 1488:37–44.

[17] Li Wu, Manli Wang, Vikramjeet Singh, Haiyan Li, Zhen Guo, Shuangying Gui, Peter York, Tiqiao Xiao, Xianzhen Yin, Jiwen Zhang*. Three dimensional distribution of surfactant in microspheres revealed by synchrotron radiation X-ray microcomputed tomography. asian journal of pharmaceutical sciences. 2017; 12:326-334.

[18] Xiaobo Wang, Jian Xiao, Hui Zhou, Ying Qiu, Hui Peng, Yangyang Sun, Jiwen Zhang, Wei Qian, Lixin Sun. Simultaneous determination of eight B‐vitamins in rat intestinal perfusate to identify effects of osmotic pressures on absorptions. Biomedical Chromatography. 2017; 9(31):3952.

[19] Vikramjeet Singh, Yaping He, Caifen Wang, Jianghui Xu, Xiaonan Xu, Haiyan Li, Parbeen Singh, Peter York, Lixin Sun**, Jiwen Zhang*. A comparison report of three advanced methods for drug-cyclodextrin interaction measurements. Journal of Pharmaceutical and Biomedical Analysis. 2017; 134:252–258.

[20] Parbeen Singh, Xiaohong Ren, Yaping He, Li Wu, Caifen Wang, Haiyan Li, Vikramjeet Singh*, Jiwen Zhang*. Fabrication of b-cyclodextrin and sialic acid copolymer by single pot reaction to site specific drug delivery. Arabian Journal of Chemistry. 2017

[21] Xue Li, Tao Guo, Laurent Lachmanski, Francesco Manoli, Mario Menendez-Miranda, Ilse Manet, Zhen Guo, Li Wu, Jiwen Zhang*, Ruxandra Gref**. Cyclodextrin-based metal-organic frameworks particles as efficient carriers for lansoprazole: Study of morphology and chemical composition of individual particles. International Journal of Pharmaceutics. 2017; 531:424–432.

[22] Zhen Guo, Fei Wu, Vikramjeet Singh, Tao Guo, Xiaohong Ren, Xianzhen Yin, Qun Shao, Peter York, Laurence H. Patterson**, Jiwen Zhang*. Host-guest kinetic interactions between HP-β-cyclodextrin and drugs for prediction of bitter taste masking. Journal of Pharmaceutical and Biomedical Analysis. 2017; 140: 232–238.

[23] Longwei Fang, Xianzhen Yin, Li Wu, Yaping He, Yuanzhi He, Wei Qin, Fanyue Meng, Peter York, Xu Xu**, Jiwen Zhang*. Classification of microcrystalline celluloses via structures of individual particles measured by synchrotron radiation X-ray micro-computed tomography. International Journal of Pharmaceutics. 2017; 531: 658–667.

[24] Li Wu, Xianzhen Yin, Zhen Guo, Yajun Tong, Jing Feng, Peter York, Tiqiao Xiao, Min Chen*, Jingkai Gu*, Jiwen Zhang**. Hydration induced material transfer in membranes of osmotic pump tablets measured by synchrotron radiation based FTIR. European Journal of Pharmaceutical Sciences. 2016; 84:132–138.

[25] Li Wu, Lebing Wang, Shuxia Wang, Tiqiao Xiao, Min Chen, Qun Shao, Peter York, Vikaramjeet Singh, Xianzhen Yin*, Jingkai Gu**, Jiwen Zhang*. Three dimensional structural insight of laser drilled orifices in osmotic pump tablets. European Journal of Pharmaceutical Sciences. 2016; 93:287–294.

[26] Li Wu, Zuhua Liao, Mingqun Liu, Xianzhen Yin, Xue Li, Manli Wang, Xiaolong Lu, Nana Lv, Vikramjeet Singh, Zhonggui He, Haiyan Li**, Jiwen Zhang*. Fabrication of non-spherical Pickering emulsion droplets by cyclodextrins mediated molecular self-assembly. Colloids and Surfaces A: Physicochem. Eng. Aspects. 2016; 490:163–172.

[27] Caifen Wang, Xiaobo Wang, Xiaonan Xu, Botao Liu, Xu Xu, Lixin Sun***, Haiyan Li**, Jiwen Zhang*. Simultaneous high-throughput determination of interaction kinetics for drugs and cyclodextrins by high performance affinity chromatography with mass spectrometry detection. Analytica Chimica Acta. 2016; 909:75-83.

[28] Botao Liu, Haiyan Li, Xiaonan Xu, Xue Li, Nana Lv, Vikramjeet Singh, J. Fraser Stoddart, Peter York, Xu Xu***, Ruxandra Gref**, Jiwen Zhang*. Optimized synthesis and crystalline stability of g-cyclodextrin metal-organic frameworks for drug adsorption. International Journal of Pharmaceutics. 2016; 514:212–219.

[29] Zhuo Li, Haiyan Li, Caifen Wang, Jianghui Xu, Vikramjeet Singh, Dawei Chen, Jiwen Zhang. Sodium dodecyl sulfate/β-cyclodextrin vesicles embedded in chitosan gel for insulin delivery with pH-selective release. Acta Pharmaceutica Sinica B. 2016; 6(4):344–351.

[30] Zhen Guo, Xianzhen Yin, Congbiao Liu, Li Wu, Weifeng Zhu, Qun Shao, Peter York***, Laurence Patterson**, Jiwen Zhang*. Microstructural investigation using synchrotron radiation X-ray microtomography reveals taste-masking mechanism of acetaminophen microspheres. International Journal of Pharmaceutics. 2016; 499:47–57.