个人情况介绍、概览
翟英雷,男,博士,教授。2004年毕业于天津大学,获化学工程与工艺学士学位,2009年获天津大学材料化学工程博士学位(硕博连读)。2012年进入沈阳药科大学医疗器械学院工作,2019年被聘为沈阳药科大学教授,现任医疗器械学院生物医用材料教研室副主任。作为课题负责人主持了国家自然科学基金青年基金项目1项,辽宁省自然科学基金1项,辽宁省教育厅一般研究项目1项,沈阳药科大学青年教师事业发展支持计划基金1项,另外,作为项目骨干成员承担国家自然科学基金面上项目2项。目前已在ACS Nano, Biomacromolecules, Molecular Pharmaceutics, Asian Journal of Pharmaceutical Sciences等期刊发表论文10余篇。
人才称号、社会兼职等
1.辽宁省第八批“百千万人才工程”万人层次人选;
2.《Asian Journal of Pharmaceutical Science》青年编委;
主要研究方向
研究方向一:生物医用高分子材料的设计与合成
研究方向二:纳米药物递释系统的研究
研究方向三:创伤修复材料和止血材料等无源医疗器械的开发
主持、参与的科研项目(含科研获奖等情况)
1.远程控制化疗协同光动力治疗的ROS敏感型纳米药物递释系统的研究,国家自然科学基金青年科学基金项目,基金编号81603053(负责人)
2.基于贻贝仿生的软组织胶黏剂的合成及性能研究,辽宁省自然科学基金,基金编号2019-ZD-0465(负责人)
3.基于环糊精-聚酸酐接枝共聚物口服纳米给药系统的构建,辽宁省教育厅一般研究项目,基金编号L2013394(负责人)
近年来发表代表性论文(限第一作者或通讯作者,SCI须写明影响因子):
1. Menglin Wang, Yinglei Zhai, Hao Ye, Qingzhi Lv, Bingjun Sun, Cong Luo, Qikun Jiang, Haotian Zhang, Youjun Xu, Yongkui Jing, Leaf Huang, Jin Sun, Zhonggui He, High Co-Loading Capacity and Stimuli-Responsive Release Based on Cascade Reaction of Self-Destructive Polymer for Improved Chemo-Photodynamic Therapy. ACS Nano (IF=13.903). 2019; 13(6) : 7010-7023.
2. Yan Liu, Shiya Zhou, Yanlin Gao, Yinglei Zhai, Electrospun nanofibers as a wound dressing for treating diabetic foot ulcer. Asian Journal of Pharmaceutical Sciences (IF=4.016). 2019; 14(2) : 130-143.
3. Yinglei Zhai, Xing Zhou, Zhiqiang Zhang, Lei Zhang, Dianyu Wang, Xinhui Wang and Wei Sun, Design, Synthesis, and Characterization of Schiff Base Bond-Linked pH-Responsive Doxorubicin Prodrug Based on Functionalized mPEG-PCL for Targeted Cancer Therapy. Polymers (IF=3.164). 2018; 10(10) : 1127.
4. Zhou Shiya, Sun Wei and Zhai Yinglei, Amphiphilic block copolymer NPs obtained by coupling ricinoleic acid/sebacic acids and mPEG: Synthesis, characterization, and controlled release of paclitaxel. Journal of biomaterials science, Polymer edition (IF=2.121). 2018; 29(18) : 2201-2217.
5. Zhai, Yinglei, Zhou, Xing, Jia, Lina, Ma, Chao, Song, Ronghua, Deng, Yanhao, Hu, Xueyao, Sun, Wei, Acetal-Linked Paclitaxel Polymeric Prodrug Based on Functionalized mPEG-PCL Diblock Polymer for pH-Triggered Drug Delivery. Polymers (IF=2.935). 2017; 9(12) : 698.
6. Wang M, Sun J, Zhai Y, Lian H, Luo C, Li L, Du Y, He Z. Enteric Polymer Based on pH-Responsive Aliphatic Polycarbonate Functionalized with Vitamin E To Facilitate Oral Delivery of Tacrolimus. Biomacromolecules (IF=5.750). 2015; 16(4) : 1179-90.
7. Zhang D, Pan X, Wang S, Zhai Y, Guan J, Fu Q, He Z, Sun J. Multifunctional Poly(methyl vinyl ether-co-maleic anhydride)-graft-hydroxypropyl-β-cyclodextrin Amphiphilic Copolymer as an Oral High-Performance Delivery Carrier of Tacrolimus (IF=4.384). Molecular Pharmaceutics. 2015; 12(7) : 2337-51.
8. Fu, Q, Li, B, Zhang, D, Fang, M. M, Shao, J. B, Guo, M. R, Guo, Z. B, Li, M, Sun, J, Zhai, Y. L, Comparative studies of the in vitro dissolution and in vivo pharmacokinetics for different formulation strategies (solid dispersion, micronization, and nanocrystals) for poorly water-soluble drugs: A case study for lacidipine (IF=3.902). Colloids and Surfaces B-Biointerfaces, 2015; 132, 171-176.
专利及其他
1.翟英雷,孙进,王萌霖,何仲贵. 2016.一种维生素E修饰的肠溶聚碳酸酯的制备及在口服给药中的应用. ZL 201410713283.4