个人情况介绍、概览
姜琪坤,男,博士,特聘教授。2010年毕业于沈阳药科大学,获药学学士学位,2013年于同校获分析化学硕士学位,2019年获沈阳药科大学药剂学博士学位,2019年-2022年于沈阳药科大学从事师资博士后工作;2022年作为高层次引进人才破格晋升为沈阳药科大学特聘教授,担任无涯创新学院孙进课题组PI助手。作为课题负责人主持或参与了国家及省市级项目7项;申请专利6项,其中2项专利已转让,具有良好的经济效益和社会效益。获得沈阳市自然科学学术成果二等奖(排名第一)、全国博士后创新创业大赛优胜奖(排名第二)、第五届全国分析药理学学术大会青年优秀论文奖(排名第一)。目前已在Acta. Pharm. Sin. B., J.Med. Chem.,Nano.Res.等期刊发表论文10余篇。
人才称号、社会兼职等
1.沈阳市高层次人才
2.沈阳药科大学“优青”
主要研究方向
研究方向一:基于前药技术的改良型新药研究
研究方向二:纳米药物递送系统研究
主持、参与的科研项目(含科研获奖等情况)
1.谷氨酰胺类似物抗肿瘤前药的发现与优化,中国博士后科学基金会面上项目,基金编号2021M693868(负责人)
2.基于PEPT1转运/APN活化的谷氨酰胺类似物抗肿瘤前药的发现与优化,辽宁省科技厅博士启动项目,基金编号2021-BS-133(负责人)
3.大豆苷元高效口服前药的研究,辽宁省教育厅基本科研项目(面上项目)(负责人)
4.基于PEPT1转运/BPHL激活的宝藿苷I的高效口服前药,中药制药过程新技术国家重点实验室开放基金项目,基金编号SKL2020M0202(负责人)
5.羟基黄酮类化合物的高效口服前药研究,天然药物仿生药物国家重点实验室开放基金项目,基金编号K202215(负责人)
6.羟脯氨酸-丝氨酸治疗自身免疫性疾病的初步药效学研究,企业技术服务项目,项目编号2021-0-4-035(负责人)
7.基于凋亡小体提升纳米药物肿瘤深部渗透策略及其相关递药机制研究,国家自然科学基金委,基金编号82273874(参与人)
近年来发表代表性论文(限第一作者或通讯作者,SCI须写明影响因子):
1.Jiang, Q.*; Lu, S.*; Xu, X.; Bai, C.; Yan, Q.; Fang, M.;Huang,L.;Jin,C.;Zhang,Y.;Sun,J.;He,Z.;Zhao,C.#;Qin,F.#;Wang,Y.#; Zhang, T#. Inhibition of alanine-serine-cysteine transporter 2-mediated auto-enhanced photodynamic cancer therapy of co-nanoassembly between V-9302 and photosensitizer. Journal of Colloid and Interface Science, DOI: 10.1016/j.jcis.2022.05.044.(IF=9.965)
2.Jiang, Q.*; Xu, Q.*; Wang, Y.; Li, P.; Zhang, Y.; Wang, Y.; Sun,J.;Zhang,T.; He, Z. Modulation of Naturally Occurring Linear Dipeptide Chirality to Reduce the Affinity for Oligopeptide Transporter 1 and Increase Intestinal Stability for an Enhanced Colon-Targeting Effect in the Treatment of Inflammatory Bowel Disease: An Application of trans-4-l-Hydroxyprolyl-l-serine. Journal of Medicinal Chemistry, DOI: 10.1021/acs.jmedchem.1c01276.(IF=8.039)
3.Jiang, Q.; Zhang, J.; Tong, P.; Gao, Y.; Lv, Y.; Wang, C.;Luo,M.;Sun,M.;Wang,J.;Feng,Y.;Cao,L.;Wang,G.;Wang,Y.;Kan,Q.;Zhang,T.;Wang,Y.;Liu,K.;Sun,J.#; He, Z.#Bioactivatable pseudotripeptidization of cyclic dipeptides to increase the affinity toward oligopeptide transporter 1 for enhanced oral absorption: an application to cyclo (l-Hyp-l-Ser)(JBP485). Journal of Medicinal Chemistry, DOI: 10.1021/acs.jmedchem.9b00358.(IF=6.205)
4.Wang, T.; Zhang, Y.; Chi, M.; Zhao, C.; Cao, L.; Tian, C.;K. Kamei;Jiang, Q.#A novel fixed-combination timolol-netarsudil-latanoprost ophthalmic solution for the treatment of glaucoma and ocular hypertension. Asian Journal of Pharmaceutical Sciences, DOI: 10.1016/j.ajps.2022.11.001.( IF=9.273)
5.Wang, Y.;Yu, J.;Li, D.;Zhao, L.;Sun, B.;Wang, J.;Wang, Z.; Zhou,S.;Wang,M.;Yang,Y.;Liu,H.;Zhang,H.;Lv,Q.;Jiang,Q.#;He,Z.#;Wang,Y#. Paclitaxel derivative-based liposomal nanoplatform for potentiated chemo-immunotherapy. Journal of Controlled Release., DOI: 10.1016/j.jconrel.2021.12.023.(IF=11.467)
6.Sun, Y.; Zhao, D.; Wang, G.; Wang, Y.; Cao, L.; Sun, J.;Jiang, Q.#; He, Z.#Recent progress of hypoxia-modulated multifunctional nanomedicines to enhance photodynamic therapy: opportunities, challenges, and future development. Acta Pharmaceutica Sinica B, DOI: 10.1016/j.apsb.2020.01.004.(IF=11.413)
7.Li, Y.; Zhang, R.; Zhang, Q.; Luo, M.; Lu, F.; He, Z.;Jiang, Q.#; Zhang, T#. Dual strategy for improving the oral bioavailability of resveratrol: Enhancing water solubility and inhibiting glucuronidation. Journal of Agricultural and Food Chemistry, DOI: 10.1021/acs.jafc.1c02602.(IF=5.895)
8.Sun, M.; Ban, W.; Ling, H.; Yu, X.; He, Z.;Jiang, Q.#; Sun, J.#Emerging nanomedicine and prodrug delivery strategies for the treatment of inflammatory bowel disease. Chinese Chemical Letters, DOI: 10.1016/j.cclet.2022.03.061.(IF=8.455)
9.Dong, F.*;Jiang, Q.*; Li, L.; Liu, T.; Zuo, S.; Gao, L.; Fang, M .;Gao, Y.; Sun, B.; Luo, C.; He, Z.#; Sun, J.#Synergetic lethal energy depletion initiated by cancer cell membrane camouflaged nano-inhibitor for cancer therapy. Nano Research, DOI: 10.1007/s12274-021-3948-0.(IF=10.269)
10.Wang, Q.*;Jiang, Q.*; Li, D.; Li, C.; Feng, Y.; Yang, Z.; He, Z.; Luo ,C.#; Sun, J.#Self-adaptive non-covalent albumin-binding near-infrared probe conjugates enabling precise sentinel lymph node metastasis illumination and primary tumor imaging. Nano Research, DOI: 10.1007/s12274-022-4884-5.(IF=10.269)
专利及其他
1.姜琪坤;马宏达;邱诗;何仲贵;孙进;王永军;申请号:202111261378.3;
2.姜琪坤;马宏达;邱诗;何仲贵;王永军;张天虹;申请号:202111262491.3
3.姜琪坤;王涛;赵晨;迟美玲;申请号:202210550653.1
4.姜琪坤;黄莉;李红敏;申请号:202210464377.7
5.何仲贵;姜琪坤;张天虹;孙进;授权号:CN 105833284 B
张天虹;李颖超;何仲贵;姜琪坤;许佑君;孙进;申请号:201910546518.