个人情况介绍、概览
宋艳志,女,博士,副教授。2007年毕业于沈阳药科大学,获理学学士学位,2010年于同校获药物制剂硕士学位,2014年获沈阳药科大学药剂学博士学位。作为课题负责人主持国家自然科学基金青年基金项目1项,辽宁省博士启动基金1项,辽宁省教育厅科学研究项目1项,沈阳药科大学-中国远大集团医药创新发展基金1项,沈阳药科大学青年教师启动基金1项。另外,作为项目骨干成员参与国家自然科学基金面上项目2项。发表SCI论文17篇,第一/通讯作者论文8篇。
人才称号、社会兼职等
1.世界中医药学会联合会中药药剂专业委员会会员;
2.《Asian Journal ofPharmaceutical Sciences》杂志审稿人;
主要研究方向
研究方向一:抗肿瘤药物的靶向递送
研究方向二:药物新型给药系统的创新研究;
主持、参与的科研项目(含科研获奖等情况)
1.针对肿瘤早期的基于单核细胞递送唾液酸修饰脂质体重塑/清除M2型肿瘤相关巨噬细胞的靶向治疗策略,国家自然科学基金青年基金,基金编号:8170131389(负责人) 2.巧妙利用肿瘤相关巨噬细胞形成通路靶向递送共载肿瘤抑素小肽T7和阿霉素脂质体,辽宁省博士科研启动基金,基金编号:2016011189-301(负责人)
3.针对M2型肿瘤相关巨噬细胞的免疫组合疗法,辽宁省教育厅科学研究一般项目,基金编号:201610163L04(负责人)
4. TAM靶向的表阿霉素脂质体及其相关SA衍生物,沈阳药科大学-中国远大集团医药创新发展基金:(负责人)
5.“MPS通路”和“EPR效应”靶向策略在肿瘤治疗中的功效评价,沈阳药科大学青年教师启动基金(负责人)
近年来发表代表性论文
1.Yanzhi Song,Qingjing Tian,Zhenjun Huang,Di Fan,Zhennan She,Xinrong Liu,Xiaobo Cheng,Bin Yu,Yihui Deng*. Self-assembled micelles of novel amphiphilic copolymercholesterol-coupled F68 containing cabazitaxel as a drug delivery system [J].International Journal of Nanomedicine, 2014, 9:2307-2317.(IF:4.383)
2.Yanzhi Song,Zhenjun Huang,Yang Song,Qingjing Tian,Xinrong Liu,Zhennan She,Jiao Jiao,Eliza Lu,Yihui Deng*. The application of EDTA in drug delivery systems: doxorubicinliposomes loaded via NH4EDTA gradient [J]. International Journal ofNanomedicine, 2014, 9:3611-3621.(IF:4.383)
3.YanzhiSong, Jie Han, Rui Feng, Mengjing Wang, Qingjing Tian, Ting Zhang, XinrongLiu, Xiaobo Cheng, Yihui Deng*. The12-3-12 cationic Gemini surfactant as a novel gastrointestinal bioadhesivematerial for improving the oral bioavailability of coenzyme Q10 nakednanocrystals [J]. Drug Development and Industrial Pharmacy, 2016, 42(12):1-25.(IF:2.295)
4.Qingjing Tian, Jia Shi, Xiaoyun Zhao, Donghua Di, Yihui Deng,Yanzhi Song*. The antitumor efficacy ofdocetaxel is enhanced by encapsulation in novel amphiphilic polymercholesterol-coupled tocopheryl polyethylene glycol 1000 succinate micelles [J].DrugDelivery and Translational Research, 2017,7:642–653.(通讯)(IF:3.094)
5. LigangGuo, Le Kang, Xinrong Liu, Xiangyun Lin, Donghua Di, Yong Wu,Dexian Kong,YihuiDeng,Yanzhi Song*.A novelnanosuspension of andrographolide: Preparation, characterization and passiveliver target evaluation in rats [J].European Journal of Pharmaceutical Sciences,2017, 104, 13-22.(通讯)(IF:3.756)
6. TangLi, Li Chen, Yihui Deng, Xin rong Liu, Xiaoyun Zhao, Yiwen Cui, Jia Shi, RuiFeng,Yanzhi Song*. Cholesterolderivative-based liposomes for gemcitabine delivery: preparation, in vitro andin vivo characterization [J]. Drug Development and Industrial Pharmacy, 2017,43:12, 2016-2015.(通讯)(IF:2.295)
7. Jiashi, Songlei Zhou, Le Kang, Ling Hu, Jiepeng Chen, Lili Duan,Yanzhi Song*and Yihui Deng*.Evaluation of the antitumor effects of vitamin K2 (menaquinone-7) nanoemulsionsmodified with sialic acid-cholesterol conjugate [J].Drugdeliveryand translational research.https://doi.org/10.1007/s13346-017-0424-1. (通讯)(IF=3.094)
8. Kaifan Liang, LirongWang, Yuqing Su,Mengyang Liu, Rui Feng,Yanzhi Song*and Yihui Deng*.Comparison among different “revealers” in the study of accelerated bloodclearance phenomenon [J]. EuropeanJournal of Pharmaceutical Sciences.https://doi.org/10.1016/j.ejps.2017.12.010. (通讯)(IF=3.756)
专利及其他
1.邓意辉,宋艳志,田清菁,刘欣荣,王旭玲,苏钰清,全晶晶,李博群,PSA-TPGS偶联物及应用.201610457682.8
2.邓意辉,宋艳志,田清菁,范迪,黄振君,刘欣荣,张婷,全晶晶,程晓波,佘振南,聚乙二醇维生素E琥珀酸酯-胆固醇碳酸酯的合成及其制备方法和应用.201410056873.4
3.邓意辉,宋艳志,刘欣荣,田清菁,隋月,蒋宫平,程晓波,胆固醇-泊洛沙姆-胆固醇三嵌段共聚物及其制备方法和应用.201310181525.5