个人情况介绍、概览

亀井謙一郎，男，博士，教授。1998年毕业于东京工业大学，获生物工程学士学位，2000年于同校获生物工程硕士学位，2003年获同校博士学位，毕业后赴美国University of California Los Angeles进行博士后研究并担任该校助理研究员。现任日本京都大学高等研究院物质细胞统合中心主任研究员（PI），2020年被聘为沈阳药科大学教授，作为课题负责人主持了国家和地区项目16项，已完成10项。申请PCT发明专利10项，获得授权7项。目前已在Nature Commun, Small, Biomaterials, Adv. Healthc. Mater, Lab on a Chip等国际著名期刊上以第一或通讯作者发表论文。

人才称号、社会兼职等

1.辽宁省兴辽英才计划-国外引进创新领军人才

2.国际干细胞研究学会（ISSCR）会员

3.日本组织培养学会会员

4.日本化学会会员

5.日本再生医疗学会会员

6.日本电气学会会员

7.《Organs-on-a-Chip》杂志编委

主要研究方向

研究方向一：微流控技术为基础的拟器官芯片及精准药物制剂筛选

研究方向二：多功能干细胞及再生器官

研究方向三：再生医学（可移植纳米纤维）

主持、参与的科研项目（含科研获奖等情况）

1.前沿3D组织工程与微流控技术，日本学术振兴会（负责人）

2.Body on a chip实现生物体系动态节律，日本学术振兴会（负责人）

3.研发多器官芯片在体外再现生理实况，国立日本研究医疗开发机构（AMED）项目（负责人）

4.基于微纳米技术的人iPS细胞在再生医疗和药物创新上的应用研究，辽宁省科技厅（负责人）

5.日德联合研究体外模型装置细胞代谢实时监测技术，日本学术振兴会（负责人）

6.机械刺激引导轴突的分子和动力学基础，日本学术振兴会（负责人）

7.Body on a chip作为濒危动物的体外模型，日本学术振兴会（负责人）

8.心脏组织工程:微纤维技术与太赫兹波的集成，日本学术振兴会（负责人）

9.Body on a chip：人多能干细胞的体外模型，Terumo生命科学基金（负责人）

10.体外人工细胞外微环境与细胞调控机制研究，日本学术振兴会（负责人）

近年来发表代表性论文(限第一作者或通讯作者，SCI须写明影响因子)：

1.K. Kamei^*, Y. Mashimo^†, M. Yoshioka, Y. Tokunaga, C. Fockenberg, S. Terada, M. Nakajima, T. Shibata-Seki, L. Liu, T. Akaike, E. Kobatake, E. S. How, M. Uesugi and Y. Chen^*. Microfluidic-nanofiber hybrid array for screening of cellular microenvironments. Small, 13(18), 1603104 (2017); DOI: 10.1002/smll.201603104.(IF=11.459)

2.L. Liu, M. Yoshioka, M. Nakajima, A. Ogasawara, J. Liu, K. Hasegawa, S. Li, J. Zou, N. Nakatsuji,K. Kamei^*and Y. Chen^*.Nanofibrous gelatin substrates for long-term expansion of human pluripotent stem cells. Biomaterials, 35, 6259-6267 (2014); DOI:10.1016/j.biomaterials.2014.04.024.(IF=10.317)

3.L. Liu^†,K. Kamei^*, M. Yoshioka, M. Nakajima, J.J. Li, N. Fujimoto, S. Terada, Y. Tokunaga, Y. Koyama, H. Sato, K. Hasegawa, N. Nakatsuji and Y. Chen. Nano-on-micro fibrous extracellular matrices for scalable expansion of human ES/iPS cells. Biomaterials, 124, 47-54 (2017); DOI: 10.1016/j.biomaterials.2017.01.039.(IF=10.317)

4.S. Diring, D. O. Wang, C. Kim, M. Kondo, Y. Chen, S. Kitagawa,K. Kamei^*and S. Furukawa^*. Localized cell stimulation by nitric oxide using a photoactive coordination polymer platform.

Nature Commun., 4, Article# 2684 (2013); DOI: 10.1038/ncomms3684.(IF=12.121)

5.K. Kamei^*, Y. Koyama, Y. Tokunaga, Y. Mashimo, M. Yoshioka, C. Fockenberg, M. Nakashima, R. Mosbergen, O. Korn, J. Li, C. Wells and Y. Chen^*. Characterization of phenotypic and transcriptional differences in human pluripotent stem cells under two- and three-dimensional culture conditions. Adv. Healthc. Mater., 5(22), 2951-2958 (2016); DOI: 10.1002/adhm.201600893.(IF=7.367)

6.K. Kamei^*, Y. Hirai^†, Y. Makino, M. Yoshioka, Q. Yuan, M. Nakajima, Y. Chen, and O. Tabata^*. Phenotypic and transcriptional modulation of human pluripotent stem cells induced by nano/microfabrication materials. Adv. Healthc. Mater., 2(2), 287-291 (2013); DOI: 10.1002/adhm.201200283.(IF=7.367)

7.R. Abdalkader,K. Kamei*. Multi-corneal barriers-on-a-chip to recapitulate eye blinking shear stress forces. Lab on a Chip, 15(2), 4277-4285 (2020).(IF=6.774)

8.K. Kamei^*, M. Ohashi, E. Gschweng, Q. Ho, J. Suh, Z. T. F. Yu, J. Tang, A. T. Clark, A. D. Pyle, M. A. Teitell, K.-B. Lee, O. N. Witte and H.-R. Tseng^*. Microfluidic Image Cytometry for Quantitative Single-Cell Profiling of Human Pluripotent Stem Cells in Chemically Defined Conditions. Lab Chip, 10(9), 1113-1119 (2010).(IF=6.774)

9.K. Kamei^†, S. Guo^†, Z. T. F. Yu^‡, H. Takahashi, E. Gschweng, X. Wang, C. Suh, J. Tang, J. McLaughlin, O. N. Witte, K.-B. Lee and H.-R. Tseng. An integrated microfluidic culture device for quantitative analysis of human embryonic stem cells. Lab Chip, 9(4), 555-563 (2009).(IF=6.774)

10.K. Kamei^*, Y. Kato, Y. Hirai^*, S. Ito, J. Satoh, A. Oka, T. Tsuchiya, Y. Chen and O. Tabata, Integrated Heart/Cancer on a chip to reproduce the side effects of anti-cancer drug in vitro”

RSC Adv., 7, 36777-36786 (2017); DOI: 10.1039/C7RA07716E.(IF=3.119)

专利及其他

1.K. Kamei, M. Yamanaka.CELL CULTURING CHIP. WO/2020/095852.

2.K. Kamei,M. Yamanaka. CELL CULTURING CHIP AND PRODUCTION METHOD THEREFOR. WO/2020/095849.

3.K. Kamei, M. Yoshioka. Endodermal cell production method, liver cell production method, pancreatic cell production method, endodermal cell induction promoter, liver cell induction promoting kit, pancreatic cell induction promoting kit, and micro fluid device. WO/2016/104541.

4.K. Kamei, L. Liu, Y. Chen, et al.,Active-ester-group-containing composition for producing fibers, and cell culture scaffold material using fibers produced from active-ester-group-containing composition. WO/2015/122478.

5.K. Kamei, L. Liu, et al.,Three-dimensional culture method using biodegradable polymer and culture substrate enabling cell transplantation. WO/2016/068266.

6.K. Kamei, et al., Microfluid device and three-dimensional microculture method for cell. WO/2015/129673.

7.K. Kamei, et al., Method for three-dimensional culture of cells using fiber-on-fiber and substrate therefor. WO/2014/196549.