个人情况介绍、概览

王佳虹，女，博士，副教授。2008年毕业于沈阳药科大学，获药学学士学位，2010年于获日本北陆大学临床药理学硕士学位，2013年获日本京都药科大学药学博士学位，同年回校任职。2020年12月被聘为沈阳药科大学副教授。目前主要研究方向为糖尿病，慢性肾病等老年慢性疾病发生机制的探究。作为课题负责人主持了国家自然科学基金青年基金项目1项，辽宁省博士启动基金1项，沈阳药科大学科研专项基金1项，另外，作为项目骨干成员承担国家自然科学基金面上项目3项。目前已在Acta Pharmacologica Sinica，Biochemical Pharmacology, Food Research International, Food Chemistry-X等期刊发表论文10余篇。

主要研究方向（限填3项）

研究方向一：慢性肾病及糖尿病肾病发生机制研究（肾脏药理学）

研究方向二：血管内皮损伤、血管炎症及血管钙化发生机制研究（心血管药理学）

研究方向三：天然药物或药食同源植物及其成分对肾脏和血管的保护作用的研究

主持、参与的科研项目（含科研获奖等情况）（限填10项）

1. 基于SIRT1/NF-κB信号通路探讨丹酚酸A改善慢性肾病大鼠血管内皮损伤和炎症的调控机制，国家自然科学基金青年科学基金项目，基金编号81803769（负责人）

2. 丹酚酸A对于慢性肾病大鼠的心血管保护作用的相关研究，辽宁省博士启动基金项目，基金编号201501053（负责人）

3. 促红细胞生成素（EPO）的肾脏保护作用，沈阳药科大学青年教师科研启动基金，基金编号QNJJ2013502（负责人）

4. 酸枣仁汤活性均一多糖治疗血亏阴虚证的作用机制和药效物质基础研究, 国家自然科学基金面上项目, 基金编号82374333（参与）

5. CircCRIM1介导PGAM1去琥珀酰化调控胶质瘤细胞生物学行为的分子机制研究，国家自然科学基金面上项目, 基金编号82072793（参与）

6. Lnc00462717与PTBP1相互作用调控miR-186开放血脑肿瘤屏障的作用与机制研究，国家自然科学基金面上项目, 基金编号81773289（参与）

近年来发表代表性论文(限第一作者或通讯作者，SCI须写明影响因子)：（限填10篇）

1. Jiaohan Zhan , Jiahong Wang , Li Jiang , Jiahe Li , Jiangxin Li , Juan Cao, Yiyang Du, Tingxu Yan, Ying Jia, Bosai He；Moringa oleifera leaves water extract as a novel therapeutic agent for hyperlipidemia prevention: Integrated analysis of bioactive components and metabolic regulatory pathways，Food Research International, 2026, 225(2026):1-19(共同第一作者，IF 8.0）

2. Meiqi Han; Jiahong Wang; Zihan Zhang; Ziwei Yan; Zhiqi Wang; Xinyao Guan; Siling Wang; Yuling Mao; Jinghai Zhang; Momordica Charantia L.-derived extracellular vesicles achieve pancreatic-targeted delivery and repair insulin-secretory function through dual mechanisms via lymphatic transport, Chemical Engineering Journal, 2025, 520(2025): 1-17(共同第一作者，IF 13.2 )

3. Jiahong Wang; Juan Cao; Hao Wang; Yudie Zhang; Li Jiang; Jiaohan Zhan; Yanxiu Sun; Yiyang Du; Tingxu Yan; Ying Jia; Bosai He; In vitro identification and in vivo metabolic profiling of chemical constituents in Moringa oleifera seeds, Food Chemistry: X, 2025, 30(2025):1-17(唯一第一作者，IF 8.2 )

4. Hao Wang; Xiuli Zhao; Xiao Wang; Yi Gong; Songping Li; Yanting Gu; Bosai He; Jiahong Wang; Investigation of the role and mechanism of dapagliflozin in mitigating renal injury in rats afflicted with diabetic kidney disease, Biochemical Pharmacology, 2025, 233(2025): 1-12(唯一通讯作者，IF 5.6)

5. Jiahong Wang; Yiyang Du; Li Jiang; Jiahe Li; Bing Yu; Chuang Ren; Tingxu Yan; Ying Jia;Bosai He ; LC-MS/MS-based chemical profiling of water extracts of Moringa oleifera leaves and pharmacokinetics of their major constituents in rat plasma, Food Chemistry: X, 2024, 23: 1-12(共同第一作者，IF 5.6 )

6. Chengkai Wu; Bosai He; Xiao Wang; Yang Zou; Ruixin Ma; Yanting Gu; Jian Huang; Songping Li; Jinhui Wang; Jiahong Wang ; Salvianolic acid A alleviates cardiovascular injury in rats with chronic kidney disease by activating the PI3K/Akt/Nrf2/HO-1 and SIRT1/TLR4/ NF-κB/P38 signaling pathways, Journal of Functional Foods , 2023, 110(2023): 1-13 ( 共同通讯作者，IF 3.8 )

7. Yiyang Du; Jiahong Wang; Li Jiang; Jinyan Li; Jiahe Li; Chuang Ren; Tingxu Yan; Ying Jia; Bosai He ; Screening the components in multi-biological samples and the comparative pharmacokinetic study in healthy and depression model rats of Suan-Zao-Ren decoction combined with a network pharmacology, Journal of Ethnopharmacology , 2024, 319: 1-14 (共同第一作者，IF 5.4 )

8. Bosai He; Xiao Wang; Ying Zhang; Cheng Gao; Cheng-kai Wu; Sirui Guo; Yan-ting Gu; Qing Li; Jiahong Wang ; Anti-oxidant, anti-inflammatory, and anti-fibrotic effects of Moringa oleifera seeds on renal injury diabetic induced by streptozotocin, Journal of Functional Foods, 2022, 95: 105168-105168 (共同通讯作者，IF 5.6 )

9. Hongfeng Zhang; Jiahong Wang; Yanli Wang; Cheng Gao; Yanting Gu; Jian Huang; Jinhui Wang; Zhou Zhang; Salvianolic Acid A Protects the Kidney against Oxidative Stress by Activating the Akt/GSK-3 beta/Nrf2 Signaling Pathway and Inhibiting the NF-kappa B Signaling Pathway in 5/6 Nephrectomized Rats, Oxidative Medicine and Cellular Longevity, 2019: 2853534 (共同第一作者， IF 5.076)

10. Hongfeng Zhang; Yanli Wang; Cheng Gao; Yanting Gu; Jian Huang; Jinhui Wang; Jiahong Wang; Zhou Zhang; Salvianolic acid A attenuates kidney injury and inflammation by inhibiting NF-κB and p38 MAPK signaling pathways in 5/6 nephrectomized rats, Acta Pharmacologica Sinica, 2018, 2018(39(12)): 1855-1864 (共同通讯作者， IF 4.01)

主编或参编的教材、专著（限填10项）

1. 《人体解剖生理学实验》参编,中国医药科技出版社, 2014年8月