个人情况介绍、概览
王佳虹,女,博士,副教授。2008年毕业于沈阳药科大学,获药学学士学位,2010年于获日本北陆大学临床药理学硕士学位,2013年获日本京都药科大学药学博士学位,同年回校任职。2020年12月被聘为沈阳药科大学副教授。目前主要研究方向为糖尿病,慢性肾病等老年慢性疾病发生机制。作为课题负责人主持了国家自然科学基金青年基金项目1项,辽宁省博士启动基金1项,沈阳药科大学科研专项基金1项,另外,作为项目骨干成员承担国家自然科学基金面上项目3项。目前已在Acta Pharmacologica Sinica,Oxidative Medicine and Cellular Longevity,Journal of Separation Science等期刊发表论文10余篇。
主要研究方向
研究方向一:慢性肾病及其并发症病理发展机制及药物靶点研究
研究方向二:糖尿病并发生发展机制及分子靶向治疗
研究方向三:天然药物及中药复方药效学评价及机制研究
主持、参与的科研项目(含科研获奖等情况)
1.基于SIRT1/NF-κB信号通路探讨丹酚酸A改善慢性肾病大鼠血管内皮损伤和炎症的调控机制,国家自然科学基金青年科学基金项目,基金编号81803769(负责人)
2.丹酚酸A对于慢性肾病大鼠的心血管保护作用的相关研究,辽宁省博士启动基金项目,基金编号201501053(负责人)
3.促红细胞生成素(EPO)的肾脏保护作用,沈阳药科大学青年教师科研启动基金,基金编号QNJJ2013502(负责人)
近年来发表代表性论文(限第一作者或通讯作者,SCI须写明影响因子):
1. Chen Chen# ; Jiahong Wang #; Ruiping Cai; Yanmeng Yuan; Zhanyun Guo; Christof Grewer ; Zhou Zhang ; Identification of a Disulfide Bridge in Sodium-Coupled Neutral Amino Acid Transporter 2(SNAT2) by Chemical Modification, PLoS One., 2016,11(6).(IF=2.806)
2. Hongfeng Zhang; Yanli Wang; Cheng Gao; Yanting Gu; Jian Huang; Jinhui Wang; Jiahong Wang *, Zhou Zhang*;Salvianolic acid A attenuates kidney injury and inflammation by inhibiting NF-κB and p38 MAPK signaling pathways in 5/6 nephrectomized rats,Acta Pharmacologica Sinica, 2018:1-10.(IF=4.01)
3. Hongfeng Zhang#; Jiahong Wang#; Yanli Wang; Cheng Gao; Yanting Gu; Jian Huang; Jinhui Wang *; Zhou Zhang*; Salvianolic Acid A Protects the Kidney against Oxidative Stress by Activating the Akt/GSK-3 ,beta/Nrf2 Signaling Pathway and Inhibiting the NF-kappa B Signaling Pathway in 5/6 Nephrectomized Rats, Oxidative Medicine and Cellular Longevity, 2019:1-16.(IF=5.076)
4. Sirui Guo#; Jiahong Wang#; Huarong Xu; Weiwei Rong; Cheng Gao; Ziyue Yuan; Fucheng Xie; Kaishun Bi; Zhou Zhang*; Qing Li*;Classic Prescription, Kai-Xin-San, Ameliorates Alzheimer’s Disease as an Effective Multitarget Treatment: From Neurotransmitter to Protein Signaling Pathway, Oxidative Medicine and Cellular Longevity, 2019:1-14.(IF=5.076)
5. Sirui Guo#; Jiahong Wang#; Yunjia Wang; Ying Zhang; Kaishun Bi; Zhou Zhang*; Qing Li*; StudyontheMultitargetSynergisticEffectsofKai-Xin-Sanagainst Alzheimer’s Disease Based on Systems Biology, Oxidative Medicine and Cellular Longevity, 2019:1-15.(IF=5.076)
6. Xintong Li#; Yanan Wang#; Mingming Su; Xiaowen Chu; Siqi L; Yiqiang Yue1; Xiaoxue Zhang; Jiahong Wang*; Fei Han*; Brain metabolomics study for the protective effects of Rhodiola crenulata extract on Alzheimer’s disease by HPLC coupled with Fourier transform-ion cyclotron resonance mass spectrometry, Journal of Separation Science, 2020:1-29.(IF=2.878)
主编或参编的教材、专著
1.《人体解剖生理学实验》参编,中国医药科技出版社, 2014年8月