个人情况介绍、概览

闻家辰，男，博士，副教授。2016年毕业于沈阳药科大学，获药物化学博士学位，毕业后赴美国University of Connecticut进行博士后研究。2022年作为高层次引进人才，被聘为沈阳药科大学副教授。作为课题负责人主持了纵向课题6项，横向课题1项；作为项目骨干成员承担了国家自然科学基金、美国国立卫生研究院科研项目3项。目前已在J. Med. Chem. 等期刊发表论文30余篇，参编中文专著1部、英文专著2部，授权发明专利5件。

人才称号、社会兼职等

1.《中国药物化学杂志》青年编委；

2.《中国医药工业杂志》青年编委；

3.《中国医药导刊》青年编委；

4.《Pharmaceutical Science Advances》青年编委；

5. 辽宁省药学会第十届药物化学专业委员会委员

主要研究方向

研究方向一：细菌双组份系统的药物化学生物学研究

研究方向二：发育信号通路的药物化学研究

研究方向三：深度学习在药物结构优化中的应用研究

近年来发表代表性论文：

1. Pan R., Ding Y., Peng J., Long Y., Zhao Y., Lin Q., Wu S., Guo F., Wen J., Zhou X., Ma Y. Identification and characterization of a novel bacteriocin PFB252 from Bacillus velezensis with anti-methicillin-resistant Staphylococcus aureus and anti-biofilm activity for dairy food preservation. Journal of Dairy Science, 2026, 109, 110-126.

2. Wang S., Luo M., Xu Q., Guo R., Zhang W., Li B., Qin H., Wei L., Cui Y., Sha J., Shao S. Yu X., Zhao L., Sun P., Bai C., Wen J, Liu D. Discovery of TNI-97 as a highly selective, orally bioavailable HDAC6 inhibitor for the treatment of triple-negative breast cancer. Journal of Medicinal Chemistry, 2025, 68, 14333–14356.

3. Zhang Y., Xiao G., Ding H., Zou Q., Gu D., We, J., Pei Y., Guo R., Wang Q., Zhou X. Direct sensing of host ferric iron by an archetype histidine kinase mediates virulence of an enteric pathogen. Proceedings of the National Academy of Sciences, 2025, 122, e2507874122.

4. Li B., Chen Y., Wang S., Jin B., Yang J., Niu Q., Hao G., Wang N., Zhang W., Zhao L., Wen J., Dan L. Discovery of 4,5-dihydro-benzo[g]indazole-based hydroxamic acids as HDAC3/BRD4 dual inhibitors and anti-tumor agents. European Journal of Medicinal Chemistry, 2025, 285, 117230.

5. Guo R., Fang X., Shang K., Wen J., Ding, K. Induction of ferroptosis: A new strategy for the control of bacterial infections. Microbiological Research, 2024, 284, 127728.

6. Xing K., Zhang H., Wang S., Li J., Mu Z., Zhang L., Zuo S., Wang Y., Li S., Wu B., Jing, Y. Design, synthesis and biological evaluation of 4-(indolin-1-yl)-6-substituted-pyrido[3,2-d] pyrimidine derivatives as Mnk1/2 inhibitors. European Journal of Medicinal Chemistry, 2024, 272, 116499.

7. Deng H., Han Y., Liu L., Zhang H., Liu D., Wen J., Huang M., Zhao L. Targeting myeloid leukemia-1 in cancer therapy: Advances and directions. Journal of Medicinal Chemistry, 2024, 67, 5963-5998.

8. Wen J., Dash R.C., Zaino A.M., Harrahill N.J., Calhoun J.T., Dusek C.O., Morel S.R., Russolillo, M., Hadden, M.K. 8-Hydroxyquinoline derivatives suppress GLI1-mediated transcription through multiple mechanisms. Bioorganic Chemistry, 2023, 132, 106387.

9. Wen J., Wang S., Guo R., Liu, D. CSF1R inhibitors are emerging immunotherapeutic drugs for cancer treatment. European Journal of Medicinal Chemistry, 2023, 245, 114884.

10. Wen J., Liu D., Zhao L. Small molecules targeting γ-secretase and their potential biological applications. European Journal of Medicinal Chemistry, 2022, 232, 114169.

主编或参编的教材、专著

1.《化学制药工艺学》第六版编者, 全国高等医药院校药学类专业第六轮规划教材. 中国医药科技出版社.

2. Psychiatric Medications for Children and Adolescents with Mental Disability. The Palgrave Encyclopedia of Disability. Springer Nature Press.

3. Colony-Stimulating Factor 1 Receptor: A Novel Target for Cancer Immunotherapy. Advances in Cancer Immunotherapy. IntechOpen Press.

专利及其他

1. Hadden M.K., Dash R.C., Wen J. Transcription Factor GLI1 Inhibitors and Uses Thereof. US18438074.9.

2. 赵临襄, 刘丹, 闻家辰, 杨金玉. 一种具有抗肿瘤活性的3-取代吡唑-5-酰胺类化合物及其应用. CN105669556B.

3. 刘丹, 赵临襄, 闻家辰, 杨金玉, 包宇, 王蕊, 景永奎. 一种具有抗肿瘤活性的硫基类化合物及其应用. CN104945324B.

4. 刘丹, 赵临襄, 闻家辰, 牛群, 徐祺皓, 景永奎. 一种具有HDAC6抑制活性的硫醇类化合物及其应用. CN109384793A.

5. 赵临襄, 黄敏, 邢坤, 李景欢, 厉姝君, 刘丹, 闻家辰, 景永奎. 4-苯胺基取代吡啶并[3,2-d]嘧啶类化合物及其应用. CN119775274A.

6. 赵临襄, 黄敏, 邢坤, 穆志颖, 张澜馨, 刘丹, 闻家辰, 景永奎. 4-吲哚啉基取代吡啶并[3,2-d]嘧啶类化合物及其应用. CN119613403A.

7. 学术报告. 伊曲康唑衍生物的合理优化与PDT联合治疗食管癌探索. 第九届《药学学报》药学前沿学术研讨会. 2025. 桂林.

8. 学术报告. VbrK抑制剂的发现及逆转β-内酰胺类抗生素耐药研究. 2025中国药学会药物化学学术会议暨中欧药物化学研讨会. 2025. 乌鲁木齐.

9. 学术报告. Discovery of novel small-molecules targeting transcriptional factor GLI. Symposium of Pharmaceutical Science. 2024. Nagoya.

10. 学术报告. 靶向跨损伤合成蛋白Rev1-CT结构域的先导物发现. 第七届《药学学报》药学前沿论坛暨《药学学报》创刊70周年研讨会. 2023. 海口.