个人情况介绍、概览

孙伟，男，博士，副教授。2004年毕业于沈阳药科大学，获药学学士学位，2012年于同校获药物化学博士学位，2008-2012年赴韩国首尔国立大学药学院Lee Jeewoo教授课题组从事镇痛药物研究。2012年留校任教，2018年评为副教授。作为课题负责人，主持国家自然科学基金青年基金项目1项，辽宁省科技厅项目2项，辽宁省教育厅项目1项，沈阳药科大学科研专项基金2项及企业横向课题3项。以第一作者或通讯作者发表SCI论文10余篇。

主要研究方向

研究方向一：创新药物研发（抗肿瘤、镇痛等）

研究方向二：侧基官能化高分子单体的设计、制备

研究方向三：基于荧光的体内外诊断试剂开发

主持、参与的科研项目（含科研获奖等情况）

1.基于TPRV1三维结构的新型镇痛药物的设计、合成及镇痛作用研究，国家自然科学基金青年科学基金项目，基金编号：81502927（负责人）

2.基于TPRV1三维结构的无成瘾性新型镇痛药物的设计、合成及镇痛机制研究，辽宁省自然科学基金项目，基金编号：2015020733（负责人）

3.有效改善癌痛患者生活质量的无成瘾性镇痛药物开发”，辽宁省科学事业公益研究基金项目（负责人）

4.pH敏感型嵌段共聚物用于难溶性抗肿瘤药物靶向递送系统的设计与评价，辽宁省教育厅科学研究一般项目，基金编号：201610163L29（负责人）

5.TRPV1小分子拮抗剂的设计、合成及生物活性评价，海南省科研院所技术开发专项，基金编号：KYYS-2014-22（参与人）

近年来发表代表性论文(限第一作者或通讯作者，SCI须写明影响因子)：

1.Qida Zong, Shiya Zhou, Jing Ye, Xinxuan Peng,Huiying Wu, Mohan Li, Xuanjiayi Ye, Naixin Tian,Wei Sun#, Yinglei Zhai#,Aliphatic polycarbonate-based hydrogel dressing for wound healing, Journal of Drug Delivery Scienceand Technology, DOI: 10.1016/j.jddst.2022.104083. (IF=5.0)

2.ShuwenFu, Shilin Ma, Xinxuan Peng, Han Qiao, Wenli Zang, Jing Ye,Wenfeng Zang, Mohan Li, Kexin Shi,Wei Sun#, Yinglei Zhai#, Endocytosis-mediated triple-activable prodrug nanoparticales potentiating therapeutic efficacy and security towards solid tumors, Colloids and Surfaces B: Biointerfaces, DOI: 10.1016/j.colsurfb.2022.112723. (IF=5.8)

3. Zhiqiang Zhang, Anning Li, Xingqi Min, Qunqun Zhang,Jun Yang, Guo Chen, Meijuan Zou,Wei Sun#, Gang Cheng#, An ROS-sensitive tegafur-PpIX-heterodimer-loadedinsituinjectablethermosensitive hrdrogel for photodynamic therapy combined with chemotherapy to enhance the tegafur-based treatment of breast cancer, Biomaterials Science, DOI: 10.1039/d0bm01519a.(IF=7.59)

4.Qiu Wang, Mengchi Sun, Dan Li, Chang Li, CongLuo, Zhaomeng Wang, Wenjuan Zhang, Zimeng Yang, Yao Feng, Shuang Wang, Zhonggui He, Haotian Zhang,Qiming Kan,Wei Sun#, Jin Sun#,Cytochrome P450 enzyme-mediated auto-enhanced photodynamic cancer therapy of co-nanoassembly between clopidogrel and photosensitizer, Theranostics,DOI: 10.7150/thno.42633. (IF=11.556)

5.Yinglei Zhai, Xing Zhou, Lina Jia, Chao Ma, Ronghua Song, Yanhao Deng, Xueyao Hu,Wei Sun#,Acetal-Linked Paclitaxel Polymeric Prodrug Based on Functionalized mPEG-PCL Diblock Polymer for pH-Triggered Drug Delivery, Polymers, DOI:10.3390/polym9120698. (IF=3.364)

6.Jingdan Zhang, Xiaoxue Zhang, Yangyang Zhao, Aihua Song,Wei Sun#, Ran Yin#,Metabolic profile of Kudiezi injection in rats byUPLC coupled with Fourier transform ion cyclotron resonance massspectrometry, Journal of Separation Science, DOI: 10.1002/jssc.20170831. (IF=2.557)

7.Jihyae Ann*,Wei Sun*, Xing Zhou, Aeran Jung, Jisoo Baek, Sunho Lee, Changhoon Kim, Suyoung Yoon, Sunhye Hong, Sun Choi, Noe A. Turcios, Brienna K. A. Herold, Timothy E. Esch,Nancy E. Lewin, Adelle Abramovitz, Larry V. Pearce, Peter M. Blumberg, Jeewoo Lee#,Discovery of N-(3-fluoro-4-methylsulfonamidomethylphenyl)urea as a potent TRPV1 antagonistic template, Bioorganic & Medicinal Chemistry Letters, DOI: 10.1016/j.bmcl.2016.06.010. (IF=2.454)

8.Wei Sun*, Hyo-Shin Kim, Sunho Lee, Aeran Jung,Sung-Eun Kim, Jihyae Ann,Suyoung Yoon, Sun Choi, Jin Hee Lee, Peter M. Blumberg, Robert Frank-Foltyn, Gregor Bahrenberg, Klaus Schiene, Hannelore Stockhausen, Thomas Christoph, Sven Frormann, Jeewoo#,6,6-Fused hetero-

cyclic ureas as highly potent TRPV1 antagonists, Bioorganic &Medicinal Chemistry Letters, DOI: 10.1016/j.bmcl.2014.12.086. (IF=2.486)

9.Wei Sun*, Keliang Liu, HyungChul Ryu, Dong Wook Kang, Yong Soo Kim, Myeong Seop Kim, Yongsung Cho, Rahul S. Bhondwe, Shivaji A.Thorat, Ho Shin Kim,Larry V. Pearce, Vladimir A. Pavlyukovets, Richard Tran, Matthew A. Morgan, Jozsef Lazar, Christopher B. Ryder, Attila Toth,Peter M. Blumberg, Jeewoo#, 2-(4-Methylsulfonylaminophenyl) propanamide TRPV1 antagonists: Structure-activity relationships in theB and C-regions, Bioorganic & Medicinal Chemistry, DOI: 10.1016/j.bmc.2011.12.014. (IF=2.903)