个人情况介绍、概览
高春生，男，博士，研究员。1992年毕业于上海第二军医大学药学院，获药学学士学位，同年分配至北京军事医学研究院毒物药物研究所从事药剂学研究至今。期间分别于1999年和2006年获全日制药剂学硕士和博士学位，2007、2014年晋升为副研究员和研究员，2010、2015年任命为硕士生和博士生指导老师。作为课题负责人主持国家重大新药创制、科技攻关、军队后勤科研等省部级以上基金项目12项，经费累计6000多万元。目前已在ACS Appl. Mater. Interfaces, Acta Biomaterialia, Journal of Nanobiotechnology, International Journal of Nanomedicine, Pharmaceutics, Molecular Pharmaceutics, International Journal of Pharmaceutics, Drug Delivery,Drug DevIndPharm,AAPS PharmSciTech, J Pharm Pharm Sci., Pharm Dev Technol等期刊发表论文31篇。
人才称号、社会兼职等
1.中国药学会药剂专业委员会委员
2.中国药学会制药工程专业委员会委员
3.沈阳药科大学、河南大学、齐齐哈尔医学院兼职硕士生导师
主要研究方向
研究方向一：工业药剂学应用开发研究
研究方向二：控释药物制剂技术研究
研究方向三：仿生智能药物递送系统研究
主持、参与的科研项目（含科研获奖等情况）
1.应急药物特种制剂创新及产业化关键技术，国家重大新药创制科技重大专项，基金编号2018ZX09711003-008-001（负责人）
2.FH特效药物与医学防护核心技术研究及应用，2016年，国家科技进步一等奖（排名第6）
近年来发表代表性论文(限第一作者或通讯作者，SCI须写明影响因子)：
1.Chunhong Gao, Yuli Wang, Jiejie Sun, Yang Han, Wei Gong, Yi Li, Ye Feng, Hao Wang, Meiyan Yang, Zhiping Li, Yang Yang, Chunsheng Gao*. Neuronal mitochondria-targeted delivery of curcumin by biomimetic engineered nanosystems in Alzheimer’s disease mice. Acta Biomaterialia 2020, 108: 285–299. (IF=6.638)
2.Shiyao Fu, Meng Liang, Yuli Wang, Lin Cui, Chunhong Gao, Xiaoyang Chu, Qianqian Liu, Ye Feng, Wei Gong, Meiyan Yang, Zhiping Li, Chunrong Yang, Xiangyang Xie, Yang Yang, and Chunsheng Gao*, Dual-Modified Novel Biomimetic Nanocarriers Improve Targeting and Therapeutic Efficacy in Glioma. ACS Appl. Mater. Interfaces 2019, 11(2): 1841−1854. (IF=8.456)
3.Chaopei Zhou, Xiangyang Xie, Hong Yang, Shasha Zhang, Yinke Li, Changchun Kuang, Shiyao Fu, Lin Cui, Meng Liang, Chunhong Gao, Yang Yang, Chunsheng Gao*, Chunrong Yang, Novel Class of Ultrasound-Triggerable Drug Delivery Systems for the Improved Treatment of Tumors. Molecular Pharmaceutics 2019, 16(7): 2956−2965. (IF=4.396)
4. Xiao-Yang Chu, Wei Huang, Yu-Li Wang, Ling-Wei Meng, Li-Qing Chen, Ming-Ji Jin, Lu Chen, Chun-Hong Gao, Cheng Ge, Zhong-Gao Gao, Chunsheng Gao*, Improving antitumor outcomes for palliative intratumoral injection therapy through lecithin–chitosan nanoparticles loading paclitaxel– cholesterol complex. International Journal of Nanomedicine 2019, 14, 689-705. (IF=4.471)
5.Lu Chen, Guobao Yang,Xiaoyang Chu, Chunhong Gao, Yuli Wang, Wei Gong, Zhiping Li, Yang Yang, Meiyan Yang, Chunsheng Gao*,Polymer distribution and mechanism conversion in multiple media of phase-separated controlled-release film-coating. Pharmaceutics 2019, 11(2), pii:E80. (IF=4.773)
6.Lin Cui ,Yuli Wang ,Meng Liang, Xiaoyang Chu, Shiyao Fu, Chunhong Gao Qianqian Liu, Wei Gong, Meiyan Yang, Zhiping Li, Lian Yu, Chunrong Yang, Zhide Su, XiangyangXie, Yang Yang, Chunsheng Gao*. Dual-Modified Natural High Density Lipoprotein Particles for Systemic Glioma-Targeting Drug Delivery. Drug Delivery. 2018, 25(1): 1865-1876. (IF=3.829)
7.Yuli Wang, Meiyan Yang, Ruifang Shen, Shuai Shao, Lu Chen, Wei Gong, Li Shan, Chunsheng Gao*. Development of metoprolol tartrate-loaded sustained-release pellets: effect of talc on the mechanism of drug release. Pharm Dev Technol. 2018, 23(7): 664-673. (IF=2.347)
8.Meiyan Yang, Wei Gong, Yuli Wang, Li Shan, Ying Li, Chunsheng Gao*. Bioavailability Improvement Strategies for Poorly Water-Soluble Drugs Based on the Supersaturation Mechanism: An Update. J Pharm Pharm Sci. 2016, 19(2): 208 – 225. (IF=1.922)
9.Yuli Wang, Jingjing Dai, Xinyi Chang, Meiyan Yang, Ruifang Shen, Li Shan, Yong Qian, and Chunsheng Gao*. Model drug as pore former for controlled release of water-soluble metoprolol succinate from ethylcellulose-coated pellets without lag phase: opportunities and challenges.AAPS PharmSciTech, 2015, 16(1):35-44. (IF=2.608)
10.Meiyan Yang, Si Xie, Qiu Li, Yuli Wang, Xinyi Chang, Li Shan, Lei Sun, Xiaoli Huang, Chunsheng Gao*. Effects of polyvinylpyrrolidone both as a binder and pore-former on the release of sparingly water-soluble topiramate from ethylcellulose coated pellets. Int J Pharm, 2014, 465(1/2), 187-196. (IF=4.213)
专利及其他
1.高春生等，Metoprolol sustained-release composition and preparation method thereof，美国发明专利USP10314794
2.高春生等，穿琥宁口服药物组合物及其制备方法，中国发明专利ZL201110115171.5
3.高春生等，一种氨溴索注射剂及其制备方法，中国发明专利ZL201010195712.5