个人情况介绍、概览
吴昊，男，博士，副教授。2014年毕业于美国亚利桑那大学（University of Arizona），获化学工程学士学位，2020年5月获美国科罗拉多大学博德分校（University of Colorado Boulder）化学工程博士学位。2023年被聘为沈阳药科大学副教授。作为课题负责人主持了辽宁省博士启动基金项目1项、辽宁省教育厅项目1项、连云港博士后资助项目1项、企业横向课题5项。
主要研究方向（限填3项）
研究方向一：蛋白质药物生产工艺的优化
研究方向二：蛋白质药物稳定性研究、蛋白质制剂处方筛选
研究方向三：抗体药物免疫原性研究
主持、参与的科研项目（含科研获奖等情况）（限填10项）
1. 基于荧光染色试剂的方法快速测量蛋白质药物中的蛋白质颗粒及蛋白质聚合体，辽宁省博士启动基金计划项目，基金编号2021-BS-131（负责人）
2. 单克隆抗体和重组蛋白制剂生产工艺研究，齐鲁制药，合同编号2021-0-4-051（负责人）
3. 研究空穴现象在单克隆抗体制剂运输过程中形成机制和抵御策略, 辽宁省教育厅，JYTQN2023326（负责人）
4. 预灌封注射器及针头组件硅化前后表面形态表征和研究，华熙生物，2025-0-4-047（负责人）
近年来发表代表性论文(限第一作者或通讯作者，SCI须写明影响因子)：（限填10篇）
[1] Tiancheng Xiong, Yang Han, Zhiyun Qi, Sha Guo, Xueyan Hu, Cui Wang, Lingkun Li, Tianyu Ma, Jingyi Chen, Jinghui Li, Jing Han, Hao Wu*. Microneedle & film-forming gel transdermal delivery strategy: A novel approach for vaccine delivery, International Journal of Pharmaceutics, 2025, 682: 125905.(共同通讯作者)
[2] Sha Guo#, Meng Li#, Zhe Jia, Dongze Xu, Chuanfei Yu, Yuting Mei, Yuhao Zhao, Xuhua Duan, Xiang Guo, Pengfei He, Chunbo Cui, Cui Wang, Lingkun Li, Jialiang Du, Gangling Xu, Sixian Cao, Zhiyun Qi, Hao Wu*, Lan Wang*; Establishment of a subvisible particle profile in ophthalmic recombinant fusion protein and antibody formulations to control and monitor drug quality, International Journal of Pharmaceutics, 2025, 675: 125500.(共同通讯作者)
[3] Dongze Xu#, Sha Guo#, Zhiyun Qi, Pengfei He, Xiang Guo, Hanhan Li, Zhenhao Zhou, Xueyan Hu, Cui Wang, Chuanfei Yu*, Hao Wu*; Stability of intravenous antibody dilutions in clinical use: Differences across patient populations with varying body weights, International Journal of Pharmaceutics, 2025, 674: 125496. (共同通讯作者)
[4] Junjie Wang#, Xiang Guo#, Xingchun Jiang, Xueyan Hu a, Cui Wang, Yang Han*, Hao Wu*; The Effect of Glass Container Surface Silanol Density on Monoclonal Antibody Formulation Stability after Application of Mechanical Shock, International Journal of Pharmaceutics, 2025, 670: 125152. (共同通讯作者)
[5] Xinyue Wang#, Junjie Wang#, Yang Han#, Xingchun Jiang, Sixian Cao，Tiancheng Xiong, Xiang Guo , Cui Wang , Sha Guo, Hongying Song, Ting Dong, Le Zhang, Zhenming An, Jun Liu, Jing Han*, Hao Wu*；Utilizing a Hydrophobic Primary Container Surface to Reduce the Formation of Subvisible Particles in Monoclonal Antibody Solution Caused by Fluid Shear, European Journal of Pharmaceutics and Biopharmaceutics, 2024, 204: 114052. (共同通讯作者)
[6] Meng Li#, Hao Wu#, Shuangwang, Shengshun Wu, Jing Han*, Yang Han*; Development of Microparticles for Oral Administration of Periplaneta Americana Extract to Treat Ulcerative Colitis, Drug Delivery. 2022, 29(1): 2723-2733. (共同第一作者)
[7] Hao Wu#, Sanli Movafaghi, Irene M. Francino Urdániz, Tessa M. Rowe, Andrew Goodwin, Theodore W. Randolph*; Insulin Fibril Formation Caused by Mechanical Shock and Cavitation, Journal of Physical Chemistry B, 2021, 125(29): 8021-8027. (第一作者)
[8] Hao Wu#, Carly F. Chisholm, Meagen Puryear, Sanli Movafaghi, Samuel D. Smith, Yekaterina P Okhilchuk, Corinne S. Lengsfeld, Theodore W. Randolph*; Container Surfaces Control Initiation of Cavitation and Resulting Particle Formation in Protein Formulations After Application of Mechanical Shock, Journal of Pharmaceutical Sciences, 2020, 109(3): 1270-1280. (第一作者)
[9] Hao Wu#, Theodore W. Randolph*; Aggregation and Particle Formation During Pumping of an Antibody Formulation Are Controlled by Electrostatic Interactions Between Pump Surfaces and Protein Molecules, Journal of Pharmaceutical Sciences, 2020, 109(4): 1473-1482. (第一作者)
[10] Hao Wu#, Theodore W. Randolph*; Rapid Quantification of Protein Particles in High Concentration Antibody Formulations, Journal of Pharmaceutical Sciences, 2019, 108(3): 1110-1116 (第一作者)
专利及其他（限填10项）
(1) 吴昊、郭莎、王兰、王翠、王俊杰、王新悦，一种抗蛋白聚集的制剂容器, 2023-10-27, 中国,ZL202321122697.0
(2) 郭莎、王兰、吴昊、郭翔、梅玉婷、夏喜杰、许东泽、曹思贤、贺鹏飞、王舒卓，一种实时的微粒过滤效果测量装置及系统, 2023-12-19, 中国, ZL202310932130.8
(3) 郭莎、王兰、吴昊、王翠、贾哲、于传飞、郭翔、李萌、王文波、杜加亮、贺鹏飞、陈国庆、李灵坤、许东泽，一种体外评价生物制品稳定性的方法、系统及设备, 2023-11-24, 中国,ZL202310530432.2
(4) 郭莎、王兰、吴昊、郭翔、梅玉婷、夏喜杰、许东泽、曹思贤、贺鹏飞，一种实时进行药物过滤情况监测的装置, 2024-2-23, 中国, ZL202322031255.1
